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Making Sense of Java clearly and concisely explains the concepts, features, benefits, potential, and limitations of Java. +
Microsoft Office Essentials simply covers the things you really want to know and skips over all those esoteric features that 99 out of 100 readers never use. +
Mobile Agents is the first book to give the reader the ability to create and use powerful mobile agents on the Internet. +
MongoDB In Action is a comprehensive guide to MongoDB for application developers. The book begins by explaining what makes MongoDB unique and describing its ideal use cases. A series of tutorials designed for MongoDB mastery then leads into detailed examples for leveraging MongoDB in e-commerce, social networking, analytics, and other common applications. +
With the detailed coverage of the entire set of protocols in Multiprotocol over ATM, you can be equal to the task. +
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Node.js in Action is an example-driven tutorial that starts at square one and guides you through all the features, techniques, and concepts you'll need to build production-quality Node applications. You'll start by learning how to set up your Node development environment, including loading the community-created extensions. Next, you'll run several simple demonstration programs where you'll learn the basics of a few common types of Node applications. Then you'll dive into asynchronous programming, a model Node leverages to lessen application bottlenecks. +
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OSGi in Action is a comprehensive guide to OSGi with two primary goals. First, it provides a clear introduction to OSGi concepts with examples that are relevant both for architects and developers. The central idea of OSGi is modularity, so you start by learning about OSGi bundles. You'll then see how OSGi handles module lifecycles and follow up with how it promotes service-oriented interaction among application components. +
Enterprise OSGi shows a Java developer how to develop to the OSGi Service Platform Enterprise specification, an emerging Java-based technology for developing modular enterprise applications. Enterprise OSGi addresses several shortcomings of existing enterprise platforms, such as allowing the creation of better maintainable and extensible applications, and provide a simpler, easier-to-use, light-weight solution to enterprise software development. +
Frameworks are object-oriented programming environments for vertical application areas. This book is the first to survey this exciting new technology, its concepts, and practical applications. +
Object Technology Centers of Excellence provides guidance to those charged with managing the shift to object technology. It is the only book on the market aimed not at the project level but at the corporate level, with a focus on the infrastructures necessary for a successful transition. +
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"If there was ever a textbook for software development in PHP, this would be it." Cal Evans, Podcast Review, Zend Developer Network +
Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We will also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV). +
Background Attaining the perfect balance of health care resources is ... +
Coronaviruses (CoVs) have formerly been regarded as relatively harmless respiratory pathogens to humans. However, two outbreaks of severe respiratory tract infection, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), as a result of zoonotic CoVs crossing the species barrier, caused high pathogenicity and mortality rates in human populations. This brought CoVs global attention and highlighted the importance of controlling infectious pathogens at international borders. In this review, we focus on our current understanding of the epidemiology, pathogenesis, prevention, and treatment of SARS-CoV and MERS-CoV, as well as provides details on the pivotal structure and function of the spike proteins (S proteins) on the surface of each of these viruses. For building up more suitable animal models, we compare the current animal models recapitulating pathogenesis and summarize the potential role of host receptors contributing to diverse host affinity in various species. We outline the research still needed to fully elucidate the pathogenic mechanism of these viruses, to construct reproducible animal models, and ultimately develop countermeasures to conquer not only SARS-CoV and MERS-CoV, but also these emerging coronaviral diseases. +
Objectives To identify factors that predict repeat admission to hospital for adverse drug reactions (ADRs) in older adults. Design Population based retrospective cohort study. Setting All public and private hospitals in Western Australia. Participants 28 548 patients aged ≥60 years with an admission for an ADR during 1980-2000 followed for three years using the Western Australian data linkage system. Results 5056 (17.7%) patients had a repeat admission for an ADR. Repeat ADRs were associated with sex (hazard ratio 1.08, 95% confidence interval 1.02 to 1.15, for men), first admission in 1995-9 (2.34, 2.00 to 2.73), length of hospital stay (1.11, 1.05 to 1.18, for stays ≥14 days), and Charlson comorbidity index (1.71, 1.46 to 1.99, for score ≥7); 60% of comorbidities were recorded and taken into account in analysis. In contrast, advancing age had no effect on repeat ADRs. Comorbid congestive cardiac failure (1.56, 1.43 to 1.71), peripheral vascular disease (1.27, 1.09 to 1.48), chronic pulmonary disease (1.61, 1.45 to 1.79), rheumatological disease (1.65, 1.41 to 1.92), mild liver disease (1.48, 1.05 to 2.07), moderate to severe liver disease (1.85, 1.18 to 2.92), moderate diabetes (1.18, 1.07 to 1.30), diabetes with chronic complications (1.91, 1.65 to 2.22), renal disease (1.93, 1.71 to 2.17), any malignancy including lymphoma and leukaemia (1.87, 1.68 to 2.09), and metastatic solid tumours (2.25, 1.92 to 2.64) were strong predictive factors. Comorbidities requiring continuing care predicted a reduced likelihood of repeat hospital admissions for ADRs (cerebrovascular disease 0.85, 0.73 to 0.98; dementia 0.62, 0.49 to 0.78; paraplegia 0.73, 0.59 to 0.89). Conclusions Comorbidity, but not advancing age, predicts repeat admission for ADRs in older adults, especially those with comorbidities often managed in the community. Awareness of these predictors can help clinicians to identify which older adults are at greater risk of admission for ADRs and, therefore, who might benefit from closer monitoring.
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) is a central element of a signaling pathway involved in cell proliferation, survival, and growth. Certain mutations in this pathway result in enhanced PI3K signaling, which is associated with oncogenic cellular transformation and cancer. The aims of this study were to characterize different types of PIK3CA mutations in exons 9 and 20 in a series of primary breast carcinomas and to correlate the results with clinicopathologic parameters and survival. We used frozen tissue samples and sequenced exons 9 and 20 for a series of 241 patients with a diagnosis of breast carcinoma. We found that 15.8% of the primary breast carcinomas possessed PIK3CA mutations in either exon 9 or exon 20. The rate of PIK3CA mutations was increased in HR(+)/HER2(-) tumors (18.6%), but this difference did not reach a statistical significance. The lowest rate of mutations was observed in HR(+)/HER2(+) tumors (5.3%). No statistically significant association was found between the presence of PIK3CA mutations and the prognostic/clinical features of breast cancer, including histologic subtype, Her2 status, axillary lymph node involvement, tumor grade, and tumor stage. However, the presence of the H1047R mutation in 10 samples was associated with a statistically significantly worse overall survival. PIK3CA mutation was found to be a frequent genetic change in all breast cancer subtypes but occurred with the highest rate in HR(+)/HER2(-) tumors. Further studies are needed to validate the prognostic impact of different PIK3CA mutations. +
Dermoscopy is increasingly used by clinicians (dermatologists, family physicians, podiatrists, doctors of osteopathic medicine, etc) to inform clinical management decisions. Dermoscopic findings or images provided to pathologists offer important insight into the clinician's diagnostic and management thought process. However, with limited dermoscopic training in dermatopathology, dermoscopic descriptions and images provided in the requisition form provide little value to pathologists. Most dermoscopic structures have direct histopathologic correlates, and therefore dermoscopy can act as an excellent communication bridge between the clinician and the pathologist. In the first article in this continuing medical education series, we review dermoscopic features and their histopathologic correlates.Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved. +
"POJOs in Action is required reading for battle-weary EJB developers and for new developers who want to avoid the sins of the fathers by using lightweight frameworks. -- C# Online.NET +
