Attribut:Has abstract
De Semantic MediaWiki - Sandbox
C
Objectives To identify factors that predict repeat admission to hospital for adverse drug reactions (ADRs) in older adults. Design Population based retrospective cohort study. Setting All public and private hospitals in Western Australia. Participants 28 548 patients aged ≥60 years with an admission for an ADR during 1980-2000 followed for three years using the Western Australian data linkage system. Results 5056 (17.7%) patients had a repeat admission for an ADR. Repeat ADRs were associated with sex (hazard ratio 1.08, 95% confidence interval 1.02 to 1.15, for men), first admission in 1995-9 (2.34, 2.00 to 2.73), length of hospital stay (1.11, 1.05 to 1.18, for stays ≥14 days), and Charlson comorbidity index (1.71, 1.46 to 1.99, for score ≥7); 60% of comorbidities were recorded and taken into account in analysis. In contrast, advancing age had no effect on repeat ADRs. Comorbid congestive cardiac failure (1.56, 1.43 to 1.71), peripheral vascular disease (1.27, 1.09 to 1.48), chronic pulmonary disease (1.61, 1.45 to 1.79), rheumatological disease (1.65, 1.41 to 1.92), mild liver disease (1.48, 1.05 to 2.07), moderate to severe liver disease (1.85, 1.18 to 2.92), moderate diabetes (1.18, 1.07 to 1.30), diabetes with chronic complications (1.91, 1.65 to 2.22), renal disease (1.93, 1.71 to 2.17), any malignancy including lymphoma and leukaemia (1.87, 1.68 to 2.09), and metastatic solid tumours (2.25, 1.92 to 2.64) were strong predictive factors. Comorbidities requiring continuing care predicted a reduced likelihood of repeat hospital admissions for ADRs (cerebrovascular disease 0.85, 0.73 to 0.98; dementia 0.62, 0.49 to 0.78; paraplegia 0.73, 0.59 to 0.89). Conclusions Comorbidity, but not advancing age, predicts repeat admission for ADRs in older adults, especially those with comorbidities often managed in the community. Awareness of these predictors can help clinicians to identify which older adults are at greater risk of admission for ADRs and, therefore, who might benefit from closer monitoring.
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) is a central element of a signaling pathway involved in cell proliferation, survival, and growth. Certain mutations in this pathway result in enhanced PI3K signaling, which is associated with oncogenic cellular transformation and cancer. The aims of this study were to characterize different types of PIK3CA mutations in exons 9 and 20 in a series of primary breast carcinomas and to correlate the results with clinicopathologic parameters and survival. We used frozen tissue samples and sequenced exons 9 and 20 for a series of 241 patients with a diagnosis of breast carcinoma. We found that 15.8% of the primary breast carcinomas possessed PIK3CA mutations in either exon 9 or exon 20. The rate of PIK3CA mutations was increased in HR(+)/HER2(-) tumors (18.6%), but this difference did not reach a statistical significance. The lowest rate of mutations was observed in HR(+)/HER2(+) tumors (5.3%). No statistically significant association was found between the presence of PIK3CA mutations and the prognostic/clinical features of breast cancer, including histologic subtype, Her2 status, axillary lymph node involvement, tumor grade, and tumor stage. However, the presence of the H1047R mutation in 10 samples was associated with a statistically significantly worse overall survival. PIK3CA mutation was found to be a frequent genetic change in all breast cancer subtypes but occurred with the highest rate in HR(+)/HER2(-) tumors. Further studies are needed to validate the prognostic impact of different PIK3CA mutations. +
Dermoscopy is increasingly used by clinicians (dermatologists, family physicians, podiatrists, doctors of osteopathic medicine, etc) to inform clinical management decisions. Dermoscopic findings or images provided to pathologists offer important insight into the clinician's diagnostic and management thought process. However, with limited dermoscopic training in dermatopathology, dermoscopic descriptions and images provided in the requisition form provide little value to pathologists. Most dermoscopic structures have direct histopathologic correlates, and therefore dermoscopy can act as an excellent communication bridge between the clinician and the pathologist. In the first article in this continuing medical education series, we review dermoscopic features and their histopathologic correlates.Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved. +
Camel in Action is for developers working with integration of any kind. This highly practical book introduces Camel and shows examples of how to use it with the 45+ supported enterprise integration patterns. Written by the people who wrote the Camel code, it's up to date and distills details and insights that only people deeply involved with Camel could provide. +
Client/Server Appliactions on ATM Networks discusses ATM as the key technology for transforming the enterprise network from data-only to an integrated data, voice, video, image and multimedia corporate infrastructure. +
This unique guide covers software products and vendors active in the client/server marketplace. Over 200 products and over 250 vendors are included. +
Clojure in Action is a hands-on tutorial for the working programmer who has written code in a language like Java or Ruby, but has no prior experience with Lisp. It teaches Clojure from the basics to advanced topics using practical, real-world application examples. Blow through the theory and dive into practical matters like unit-testing, environment set up, all the way through building a scalable web-application using domain-specific languages, Hadoop, HBase, and RabbitMQ. +
Code Generation In Action covers building database access, user interface, remote procedure, test cases, and business logic code as well as code for other key system functions. +
Coffeehouse is an anthology of stories, poems and essays originally published on the World Wide Web. +
This glossary offers a complete collection of technical terms and acronyms used in the networking industry. +
Continuous Integration in .NET is a tutorial for developers and team leads that teaches you to reimagine your development strategy by creating a consistent continuous integration process. This book shows you how to build on the tools you already know--.NET Framework and Visual Studio and to use powerful software like MSBuild, Subversion, TFS 2010, Team City, CruiseControl.NET, NUnit, and Selenium. +
Core OWL 5.0 dives under the surface and into the OWL source code itself. You'll see what new capabilities OWL 5.0 offers the OWL programmer. You'll gain a deeper understanding of what OWL does on your behalf such as the OWL messaging system and its message maps. +
D
DSLs in Boo shows you how to design, extend, and evolve DSLs for .NET by focusing on approaches and patterns. You learn to define an app in terms that match the domain, and to use Boo to build DSLs that generate efficient executables. And you won't deal with the awkward XML-laden syntax many DSLs require. The book concentrates on writing internal (textual) DSLs that allow easy extensibility of the application and framework. And if you don't know Boo, don't worry you'll learn right here all the techniques you need. +
If you do large scale java apps, you probably want to have someone on the team have this book. Michael Neale +
Dependency Injection in .NET is a comprehensive guide than introduces DI and provides an in-depth look at applying DI practices to .NET apps. In it, you will also learn to integrate DI together with such technologies as Windows Communication Foundation, ASP.NET MVC, Windows Presentation Foundation and other core .NET components. +
"This book is well written ... The author does not fear to be controversial. In doing so, he writes a coherent book." --Dr. Frank J. van der Linden, Phillips Research Laboratories +
Distributed Agile in Action is the first book to directly address the unique task of going Agile in a distributed team. Rather than rehashing Agile theories, this book supplies the practical examples and step by step advice you need to help your distributed teams adopt and embrace Agile principles. It's a distilled and carefully organized learning aid for working in a distributed Agile environment, with in-depth focus on how to approach three critical components of development-People, Process and Technology. +
Doing IT Right explores IT in its full complexity. It explains fundamental issues of hardware and software structures; it illuminates central issues of networking and encapsulates the essence of client/server computing; its coverage of costing, risk assessment, and due diligence in making computing decisions is unique. +
E
Building on the bestselling first edition, EJB 3 in Action, Second Edition tackles EJB 3.1 head-on, through numerous code samples, real-life scenarios, and illustrations. This book is a fast-paced tutorial for Java EE 6 business component development using EJB 3.1, JPA 2 and CDI. Besides covering the basics of EJB 3.1, this book includes in-depth EJB 3.1 internal implementation details, best practices, design patterns, and performance tuning tips. The book also discusses using open source frameworks like Seam and Spring with EJB 3.1. +
"This book provides a great reference for the average EJB developer. It provides recipes for most common tasks that an EJB developer would need." -- Computing Reviews, Nov. 2003 +
