Malignant melanoma
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| Malignant melanoma | |
|---|---|
 Malignant melanoma. (H&E stain) | |
Classification
| |
| Has microscopic description: | melanocytic differentiation (e.g. pigment)·abnormal architecture·lack of maturation·+/-nuclear atypia - esp. nucleoli·+/-upward scatter of melanocytes·+/-asymmetry of pigmentation |
| LMDDx Light microscopic DDx: | dysplastic nevus·Spitz nevus·common nevus (nevoid melanoma)·atypical fibroxanthoma·(spindle cell) squamous cell carcinoma·leiomyosarcoma·serous carcinoma·clear cell sarcoma·others |
| Stains: | melanin |
| IHC Immunohistochemical staining, also known as immunostaining: | S-100·Melan A·HMB-45·MITF·tyrosinase |
| EM Electron microscopic features: | melanosomes |
| Site Anatomical site: | skin·sun exposed skin areas·oral mucosa·others |
| Syndromes Syndromes associated with the diagnosis: | familial melanoma |
| Signs: | ABCDE = asymmetrical·border irregular·colour (black)·diameter (>6 mm)·evolving (growing) |
| Prevalence: | common |
| ClinDDx: | pigmented skin lesions·melanocytic lesions |
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