Spitz nevus
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| Spitz nevus | |
|---|---|
 High magnification micrograph of a Spitz nevus, also known as an epithelioid and spindle-cell nevus. H&E stain. | |
Classification
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| Has microscopic description: | nests of cells·spindle·epithelioid·spindle/epithelioid (in both dermis and epidermis)·nests are vertically arranged ("hanging bananas")·+/-hyperkeratosis·+/-hypergranulosis·+/-acanthosis (thick stratum spinosum)·Kamino bodies - dense eosinophilic bodies (rare in melanoma) |
| LMDDx Light microscopic DDx: | malignant melanoma·pigmented spindle cell nevus of Reed |
| Stains: | HMB-45 -ve deep aspect·Ki-67 usu. low |
| Site Anatomical site: | skin·skin face·extremity |
| Prevalence: | uncommon |
| ClinDDx: | melanoma·melanocytic lesions |
Spitz nevus, also known as epithelioid and spindle cell nevus, is an uncommon melanocytic lesion that can be difficult to differentiate from malignant melanoma.librepathology:spitNevus
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Spitz nevus, also known as epithelioid and spindle cell nevus, is an uncommon melanocytic lesion that can be difficult to differentiate from malignant melanoma +
nests of cells +, spindle +, epithelioid +, spindle/epithelioid (in both dermis and epidermis) +, nests are vertically arranged ("hanging bananas") +, +/-hyperkeratosis +, +/-hypergranulosis +, +/-acanthosis (thick stratum spinosum) + et Kamino bodies - dense eosinophilic bodies (rare in melanoma) +
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